Description

3-[4-(n-Boc)Piperazin-1-Yl]Phenylboronic Acid Pinacol Ester is a high-value, protected boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical key intermediate in the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in Suzuki-Miyaura cross-coupling reactions and targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing a piperazine moiety.
• Suzuki-Miyaura Cross-Coupling: Used as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds between aromatic rings, essential for constructing complex biaryl structures.
• Medicinal Chemistry & Drug Discovery: Enables the rapid exploration of structure-activity relationships (SAR) by facilitating the introduction of the 3-[4-(Boc-piperazin-1-yl)]phenyl fragment into target molecules.
• Library Synthesis: Employed in parallel and combinatorial chemistry for the high-throughput generation of diverse compound libraries for screening.
• Agrochemical Research: Serves as an intermediate in the development of novel crop protection agents and herbicides.
• Material Science: Potential use in the synthesis of organic electronic materials and advanced polymers requiring specific aromatic architectures.

Basic Information

Product Name	3-[4-(n-Boc)Piperazin-1-Yl]Phenylboronic Acid Pinacol Ester
CAS No.	540752-87-2
Molecular Formula	C22H35BN2O4
Molecular Weight	402.34 g/mol
Synonyms	1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-(tert-butoxycarbonyl)piperazine; tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate; 3-[4-(N-Boc)piperazin-1-yl]benzeneboronic acid pinacol ester; N-Boc-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine; Boc-Piperazine Phenylboronic Acid Pinacol Ester; 1-Boc-4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine; 3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 3-[4-(n-Boc)Piperazin-1-Yl]Phenylboronic Acid Pinacol Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and stability. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support our clients' regulatory needs and are committed to supplying material suitable for use under cGMP guidelines for non-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. For long-term storage, consider storing at 2-8°C under inert conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.