Description

Cyclopropyl(2,5-Difluorophenyl)Methanamine is a high-purity, functionalized amine building block featuring a cyclopropyl and a difluorophenyl moiety. This compound is valued for its unique structural properties, which are critical for modulating the pharmacokinetic and pharmacodynamic profiles of advanced molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Serves as a crucial building block for creating novel herbicides, fungicides, and insecticides, where the cyclopropyl and fluorine groups can enhance biological activity and environmental stability.
• Chemical Biology Probe Development: Used in the design and synthesis of molecular probes for studying enzyme function and receptor interactions in biochemical assays.
• Material Science Research: Employed in the synthesis of specialized monomers or ligands for advanced polymers, catalysts, or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing tailored compounds for client projects.

Basic Information

Product Name	Cyclopropyl(2,5-Difluorophenyl)Methanamine
CAS No.	536695-21-3
Molecular Formula	C10H11F2N
Molecular Weight	183.20 g/mol
Synonyms	1-Cyclopropyl-1-(2,5-difluorophenyl)methanamine; (2,5-Difluorophenyl)(cyclopropyl)methanamine; Cyclopropyl(2,5-difluorophenyl)methylamine; α-Cyclopropyl-2,5-difluorobenzylamine; 536695-21-3; (Cyclopropyl)(2,5-difluorophenyl)methanamine; 2,5-Difluoro-α-cyclopropylbenzylamine
EINECS	Contact for details

Quality Control

Our Cyclopropyl(2,5-Difluorophenyl)Methanamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.