Description

2-Chloro-5-Fluoro-1H-Indole-3-Carbaldehyde is a high-purity, halogenated indole derivative serving as a critical building block in advanced organic synthesis. Its value lies in its unique molecular scaffold, which is essential for constructing complex heterocyclic compounds with targeted biological activity. This intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in developing new generations of herbicides and fungicides with specific modes of action.
• Material Science: Serves as a monomer or functional unit in the creation of specialty polymers and organic electronic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploring new chemical spaces in medicinal chemistry.
• Fluorescent Probe Synthesis: Utilized to construct indole-based fluorophores for bioimaging and diagnostic applications.

Basic Information

Product Name	2-Chloro-5-Fluoro-1H-Indole-3-Carbaldehyde
CAS No.	535925-49-6
Molecular Formula	C9H5ClFNO
Molecular Weight	197.59 g/mol
Synonyms	2-Chloro-5-fluoroindole-3-carboxaldehyde; 1H-Indole-3-carboxaldehyde, 2-chloro-5-fluoro-; 5-Fluoro-2-chloro-1H-indole-3-carbaldehyde; 2-Chloro-5-fluoro-1H-indole-3-carboxaldehyde; 2-Chloro-5-fluoroindole-3-carbaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Fluoro-1H-Indole-3-Carbaldehyde is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.