Description

5-Chloro-2-Nitrophenylboronic Acid is a versatile and highly functionalized boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables efficient cross-coupling reactions, and the chloro and nitro substituents provide orthogonal handles for further chemical elaboration. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable, high-purity intermediate for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogen and nitro groups for structural diversity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organoboron catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and sensors.
• Chemical Biology Probes: Utilized to create boronic acid-based probes and sensors for detecting biological analytes like sugars and peroxides.
• Custom Synthesis and Contract Manufacturing: A valuable substrate for custom synthesis houses and CROs/CMOs serving the global fine chemical market.

Basic Information

Product Name	5-Chloro-2-Nitrophenylboronic Acid
CAS No.	532924-25-7
Molecular Formula	C6H5BClNO4
Molecular Weight	201.37 g/mol
Synonyms	(5-Chloro-2-nitrophenyl)boronic acid; 2-Nitro-5-chlorophenylboronic acid; 5-Chloro-2-nitrobenzeneboronic acid; Boronic acid, B-(5-chloro-2-nitrophenyl)-; 532924-25-7; 5-Chloro-2-nitro phenyl boronic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Nitrophenylboronic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring material traceability and compliance with cGMP and ISO standards for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.