Description

2,2-Dimethyl-n-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Propionamide is a high-value, advanced pharmaceutical intermediate featuring a pyridine core and a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Key building block for the synthesis of complex drug candidates via palladium-catalyzed cross-coupling.
• Intermediate in the research and development of small molecule therapeutics, especially kinase inhibitors and other targeted therapies.
• Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Precursor for the creation of functionalized biphenyl and heterobiaryl scaffolds prevalent in many modern pharmaceuticals.
• Employed in process chemistry for scaling up synthetic routes to clinical trial materials.
• Serves as a reagent in academic and industrial research exploring new synthetic methodologies.

Basic Information

Product Name	2,2-Dimethyl-n-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Propionamide
CAS No.	532391-30-3
Molecular Formula	C₁₆H₂₅BN₂O₃
Molecular Weight	304.19 g/mol
Synonyms	N-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-2,2-dimethylpropanamide; 2,2-Dimethyl-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)propanamide; 2-Pyridinepropanamide, N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 2,2-dimethyl-; Propanamide, 2,2-dimethyl-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2-dimethylpropanoyl)pyridin-2-amine; Pinacol ester of 3-(2,2-Dimethylpropanamido)pyridine-2-boronic acid
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-n-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Propionamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring material traceability and reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.