Description

1-Bromo-2,3,4-Trifluoro-5-Iodobenzene is a highly functionalized halogenated benzene derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique combination of bromine, iodine, and fluorine substituents makes it exceptionally valuable for constructing complex molecules through selective cross-coupling and nucleophilic aromatic substitution reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Building Block: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties and introduce specific halogens for further functionalization.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki, Stille, and Negishi couplings, leveraging the iodine and bromine for sequential, orthogonal functionalization.
• Nucleophilic Aromatic Substitution (SNAr): The fluorine atoms, activated by the ortho/para halogens, are reactive sites for substitution with various nucleophiles, enabling diverse structural modifications.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	1-Bromo-2,3,4-Trifluoro-5-Iodobenzene
CAS No.	530145-57-4
Molecular Formula	C6HBrF3I
Molecular Weight	354.87 g/mol
Synonyms	2,3,4-Trifluoro-1-bromo-5-iodobenzene; 5-Bromo-1,2,3-trifluoro-4-iodobenzene; Benzene, 1-bromo-2,3,4-trifluoro-5-iodo-; 1-Iodo-2,3,4-trifluoro-5-bromobenzene; 2,3,4-Trifluoro-5-iodobromobenzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Quality is verified through multiple analytical techniques including HPLC, GC, NMR, and elemental analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request. We adhere to strict quality management protocols to meet the demands of research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.