Description

Benzoic Acid, 2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is a high-value, synthetically versatile boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and building block in modern organic synthesis. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates containing biaryl or substituted aromatic motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aromatic architectures.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as polymers for OLEDs or organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes, enzyme inhibitors, and other tool compounds for drug discovery programs.
• Ligand & Catalyst Development: Used as a precursor for creating novel bidentate or polydentate ligands in transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	Benzoic Acid, 2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester
CAS No.	525362-07-6
Molecular Formula	C15H21BO4
Molecular Weight	276.14 g/mol
Synonyms	2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 4-Pinacolatoboryl-2-methylbenzoic acid methyl ester; 2-Methyl-4-(pinacolatoboryl)benzoic acid methyl ester; Methyl 4-borono-2-methylbenzoate pinacol ester; (4-Methoxycarbonyl-3-methylphenyl)boronic acid pinacol ester; Arylboronic ester intermediate 525362-07-6
EINECS	Contact for details

Quality Control

Our production of this high-purity boronic ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive coupling reactions. Every lot is characterized by NMR (¹H, ¹³C, ¹¹B), HPLC, and mass spectrometry to confirm identity and purity. We provide comprehensive Certificates of Analysis (COA) detailing all critical parameters, supporting your quality and regulatory documentation needs for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.