Description

4,8-Methanoazulen-5(3H)-One,3A,4,6,7,8,8A-Hexahydro-8-Methyl-,(3Ar,4S,8R,8As)-Rel-(9Ci) is a complex, stereochemically defined bicyclic ketone that serves as a valuable advanced intermediate in organic synthesis. This compound matters for its role in constructing intricate molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and specialty fine chemicals. Research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors need this high-purity building block to explore new synthetic pathways and create molecules with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, leveraging its complex bridged ring system.
• Fine Chemical Synthesis: Serves as a sophisticated building block for creating specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Material Science Precursor: Potential intermediate in the synthesis of organic semiconductors or liquid crystals due to its rigid, polycyclic structure.
• Academic & Contract Research: An essential tool for methodology development and total synthesis projects in university and CRO laboratories.
• Catalyst & Ligand Development: Framework for constructing novel chiral ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	4,8-Methanoazulen-5(3H)-One,3A,4,6,7,8,8A-Hexahydro-8-Methyl-,(3Ar,4S,8R,8As)-Rel-(9Ci)
CAS No.	521095-03-4
Molecular Formula	C13H18O
Molecular Weight	190.28 g/mol
Synonyms	(3aR,4S,8R,8aS)-rel-4,8-Methanoazulen-5(3H)-one, 3a,4,6,7,8,8a-hexahydro-8-methyl-; rel-(3aR,4S,8R,8aS)-3a,4,6,7,8,8a-Hexahydro-8-methyl-4,8-methanoazulen-5(3H)-one; 8-Methyl-3a,4,6,7,8,8a-hexahydro-4,8-methanoazulen-5(3H)-one; Bicyclic sesquiterpene ketone derivative; Advanced chiral synthon
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity for your critical R&D and scale-up processes. Certificates of Analysis (COA) detailing specifications such as chiral purity (HPLC), enantiomeric excess, and related substances are available upon request and are aligned with cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.