Description

4-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-1,4-benzoxazine is a high-value, synthetically versatile boronic ester derivative, serving as a critical building block in modern organic synthesis. Its primary commercial value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides by facilitating the formation of complex aryl-aryl bonds.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and conductive polymers, due to its functional boronate group.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and sensors.
• Catalyst & Ligand Development: Serves as a starting material for synthesizing novel ligands and organometallic catalysts.
• Custom Synthesis & Contract Manufacturing: A vital raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Detail
Product Name	4-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-1,4-benzoxazine
CAS No.	519054-54-7
Molecular Formula	C15H22BNO3
Molecular Weight	275.15 g/mol
Synonyms	4-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-3,4-dihydro-1,4-benzoxazine; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-3,4-dihydro-2H-1,4-benzoxazine; 4-Methyl-7-(pinacolatoboryl)-3,4-dihydro-2H-1,4-benzoxazine; 4-Methyl-7-(pinacolboronato)-3,4-dihydro-2H-1,4-benzoxazine; 4-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-benzoxazine; 519054-54-7; Pinacol 4-Methyl-1,4-benzoxazine-7-boronate
EINECS	Contact for details

Quality Control

Our 4-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-1,4-benzoxazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and batch-to-batch consistency suitable for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize degradation due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.