Description

Mal-Peg6-T-Butyl Ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a protected carboxylic acid. This compound is a critical reagent for creating stable, site-specific bioconjugates through its thiol-reactive maleimide moiety. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise and reproducible linker chemistry for developing antibody-drug conjugates (ADCs), peptide modifications, and advanced drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: Used for site-specific PEGylation of cysteine-containing proteins or peptides to enhance stability, solubility, and pharmacokinetic profiles.
• Surface Functionalization: Enables the covalent attachment of biomolecules (e.g., proteins, peptides) to nanoparticles, biosensors, or other solid supports via thiol-maleimide chemistry.
• Crosslinking Reagent: Facilitates the conjugation between thiol-containing molecules and other functional groups after deprotection of the t-butyl ester.
• Drug Delivery System Development: Serves as a versatile spacer/linker in the design of polymer-drug conjugates and targeted nanocarriers.
• Diagnostic Reagent Synthesis: Employed in the preparation of fluorescent or radioactive probes for in vitro and in vivo imaging applications.

Basic Information

Product Name	Mal-Peg6-T-Butyl Ester
CAS No.	518044-37-6
Molecular Formula	C31H55NO12
Molecular Weight	633.77 g/mol
Synonyms	Maleimide-PEG6-t-butyl ester; 3-[2-[2-[2-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid tert-butyl ester; mPEG6-MAL-t-butyl ester; MAL-PEG6-OtBu; tert-Butyl 3,6,9,12,15,18-hexaoxa-22-azahenicos-20-en-21-one-22-carboxylate; 1-(8-(2-(2-(2-(2-(2-(3-(tert-butoxy)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione
EINECS	Contact for details

Quality Control

Our Mal-Peg6-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and moisture content are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.