Description

2-(2,2-Difluoro-2H-1,3-Benzodioxol-5-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 517874-23-6 is a high-purity, advanced boronic ester building block designed for sophisticated organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, particularly in the construction of complex heterocyclic and fluorinated molecular architectures. It is an essential reagent for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially those containing benzodioxole and fluorine motifs.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides that leverage its unique fluorinated aromatic structure.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its boronate ester functionality.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and bioconjugates for diagnostic and proteomics research.
• Process Chemistry & Scale-up: Provides a stable and handleable boronate source for optimizing large-scale manufacturing routes for complex molecules.

Basic Information

Product Name	2-(2,2-Difluoro-2H-1,3-Benzodioxol-5-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	517874-23-6
Molecular Formula	C15H18BF2O4
Molecular Weight	311.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2-difluoro-2H-1,3-benzodioxole; 2,2-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1,3-benzodioxole; 2,2-Difluoro-1,3-benzodioxole-5-boronic acid pinacol ester; 2,2-Difluorobenzodioxole-5-boronic acid pinacol ester; 2,2-Difluoro-1,3-benzodioxol-5-ylboronic acid pinacol ester; CAS 517874-23-6; 2,2-Difluoro-5-(pinacolatoboryl)-2H-1,3-benzodioxole
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Quality Control

Our 2-(2,2-Difluoro-2H-1,3-Benzodioxol-5-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, from early-stage R&D to cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (nitrogen or argon) when not in use to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.