Description

(R)-Borophe-(+)-Pinanediol-Cf3Co2H is a high-purity, chiral organoboron reagent featuring a trifluoromethylated carboxylate group. This compound is of significant value as a specialized building block in asymmetric synthesis and pharmaceutical research, enabling the introduction of chiral centers and fluorinated motifs. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring boron-based cross-coupling reactions (Suzuki-Miyaura).
• Asymmetric Catalysis: Serves as a ligand or catalyst component in enantioselective transformations for the production of single-enantiomer compounds.
• Agrochemical Research: Used in the development of novel, fluorinated pesticides and herbicides where the chiral boronate moiety is critical for bioactivity.
• Material Science: Employed in the synthesis of advanced organic electronic materials and liquid crystals that incorporate chiral and fluorinated components.
• Chemical Biology & Probe Development: Utilized for creating bioconjugates and molecular probes that target specific biological pathways.
• Process Chemistry & Scale-up: Provides a reliable, high-quality reagent for optimizing and scaling synthetic routes from laboratory to pilot plant.

Basic Information

Product Name	(R)-Borophe-(+)-Pinanediol-Cf3Co2H
CAS No.	514820-49-6
Molecular Formula	C₁₈H₂₀BF₃O₄
Molecular Weight	368.16 g/mol
Synonyms	(R)-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, 2-(Trifluoromethyl)-, (1R,2S,5R)-2-Hydroxy-2-pinan-3-yl ester; (R)-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-α,α,α-trifluoro-methylbenzoic acid (+)-pinanediol ester; (R)-Borophe-CF3-(+)-Pinanediol Ester; (R)-Trifluoromethylphenylboronic Acid (+)-Pinanediol Ester; (R)-α,α,α-Trifluoro-o-tolylboronic Acid (+)-Pinanediol Ester
EINECS	Contact for details

Quality Control

Our (R)-Borophe-(+)-Pinanediol-Cf3Co2H is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (HPLC) and chemical identity confirmation (NMR, IR), to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.