Description

(R,R,R,R)-2,3-Bis(2,5-Dimethyl-Phospholanyl)Benzo[B]Thiophene Cyclooctadiene Rhodium(I) Tetrafluoroborate Complex is a highly specialized, chiral transition metal catalyst essential for asymmetric synthesis. This complex is valued for its ability to induce high enantioselectivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions. It is primarily required by research and development laboratories and production facilities in the pharmaceutical and fine chemical industries for the synthesis of chiral intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines with high optical purity.
• Pharmaceutical Intermediate Synthesis: Critical for the production of enantiomerically pure intermediates used in the manufacture of chiral drugs, including β-blockers, antidepressants, and antiviral agents.
• Fine Chemical Production: Enables the synthesis of complex, high-value chiral molecules for agrochemicals, flavors, and fragrances.
• Academic & Industrial R&D: Serves as a key reagent in method development and discovery chemistry for exploring new asymmetric transformations.
• Process Chemistry Optimization: Used to develop and scale up efficient, selective catalytic processes for commercial manufacturing.

Basic Information

Product Name	(R,R,R,R)-2,3-Bis(2,5-Dimethyl-Phospholanyl)Benzo[B]Thiophene Cyclooctadiene Rhodium(I) Tetrafluoroborate Complex
CAS No.	511543-00-3
Molecular Formula	C31H42BF4P2RhS
Molecular Weight	678.39 g/mol
Synonyms	(R,R,R,R)-DuanPhos Rhodium(I) Tetrafluoroborate COD Complex; Rh((R,R)-DuanPhos)(COD)BF4; (R,R,R,R)-2,3-Bis(2,5-dimethylphospholanyl)benzothiophene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; DuanPhos-Rh(COD)BF4; (R,R)-DuanPhos Rhodium Catalyst; [Rh((R,R)-DuanPhos)(nbd)]BF4 (related complex); Asymmetric Hydrogenation Catalyst Rh-DuanPhos; (R,R)-2,3-Bis(2,5-dimethylphospholanyl)benzo[b]thiophene rhodium complex
EINECS	Contact for details

Quality Control

Every batch of our (R,R,R,R)-2,3-Bis(2,5-Dimethyl-Phospholanyl)Benzo[B]Thiophene Cyclooctadiene Rhodium(I) Tetrafluoroborate Complex is manufactured and tested under strict quality management protocols to ensure consistent catalytic performance and enantioselectivity. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral integrity, and metal content. Our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use to exclude air and moisture.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	14.0 - 16.0 %
Enantiomeric Purity	≥ 99% ee (by chiral HPLC or NMR of derivative)
Solubility	Soluble in dichloromethane, acetone; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.