Description

3-Bromo-5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoxazole is a high-value, multi-functional heterocyclic building block that serves as a critical intermediate in modern synthetic chemistry. Its core value lies in the combination of a reactive bromine substituent and a protected boronic ester (pinacol boronate) group, enabling sequential cross-coupling reactions for the efficient construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in constructing biaryl and heterobiaryl motifs common in drug candidates.
• Agrochemical Synthesis: Used to create complex heterocyclic compounds for next-generation herbicides, fungicides, and insecticides, leveraging its versatile reactivity.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular structure is critical.
• Chemical Biology & Probe Development: Serves as a building block for creating molecular probes and labeled compounds used in biochemical assays and diagnostic research.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel and combinatorial chemistry approaches in medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals on scale.

Basic Information

Product Name	3-Bromo-5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoxazole
CAS No.	509152-20-9
Molecular Formula	C10H15BBrNO3
Molecular Weight	288.95 g/mol
Synonyms	3-Bromo-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole; 4-(3-Bromo-5-methylisoxazol-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-5-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole; 3-Bromo-5-methylisoxazole-4-boronic acid pinacol ester; 3-Bromo-5-methyl-4-(pinacolatoboryl)isoxazole; 509152-20-9; 3-Bromo-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoxazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.