Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Aniline is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the efficient construction of complex molecules through reliable cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular scaffolds for drug discovery, crop protection agents, and organic electronic materials. The CAS number for this compound is 508223-55-0.

Application

This versatile boronic ester is a key intermediate in the synthesis of complex organic molecules. Its primary and related applications include:

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing the trifluoromethyl group, which is prized for its metabolic stability and lipophilicity in drug design.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the aniline and boronic ester functionalities allow for the creation of diverse bioactive structures.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) for electronic and photonic applications.
• Cross-Coupling Reactions: Primarily serves as a reliable partner in Suzuki-Miyaura cross-coupling reactions to form biaryl and other carbon-carbon bonds under mild conditions.
• Chemical Biology & Proteomics: Can be utilized as a handle for bioconjugation or in the synthesis of molecular probes and inhibitors for target identification.
• Custom Synthesis & R&D: A valuable starting material for contract research organizations (CROs) and academic laboratories engaged in novel synthetic route development and medicinal chemistry programs.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Aniline
CAS No.	508223-55-0
Molecular Formula	C13H17BF3NO2
Molecular Weight	287.09 g/mol
Synonyms	2-(Trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzenamine; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzotrifluoride; Pinacol [2-Amino-5-(trifluoromethyl)phenyl]boronate; [2-Amino-5-(trifluoromethyl)phenyl]boronic acid pinacol ester; 4-Amino-3-(trifluoromethyl)phenylboronic acid pinacol ester; B-[2-Amino-5-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Aniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for your critical synthesis. Products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We can support development and commercial projects requiring compliance with ICH guidelines and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.