Description

4,4,5,5-Tetramethyl-2-(3-Methyl-5-Nitrophenyl)-1,3,2-Dioxaborolane is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical Suzuki-Miyaura cross-coupling reagent, enabling the efficient construction of complex biaryl structures essential in modern organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Employed in the development of organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes.
• Academic & Industrial R&D: Fundamental reagent for methodological development in palladium-catalyzed cross-coupling reactions.
• Fine Chemical Production: Enables the scalable, precise synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(3-Methyl-5-Nitrophenyl)-1,3,2-Dioxaborolane
CAS No.	508178-15-2
Molecular Formula	C13H18BNO4
Molecular Weight	263.10 g/mol
Synonyms	(3-Methyl-5-nitrophenyl)boronic acid pinacol ester; 2-(3-Methyl-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methyl-5-nitrophenylboronic acid pinacol ester; Pinacol (3-methyl-5-nitrophenyl)boronate; 5-Nitro-m-tolylboronic acid pinacol ester; B-(3-Methyl-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of our 4,4,5,5-Tetramethyl-2-(3-Methyl-5-Nitrophenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high standards required for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all commercial and research quantities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.