Description

2-Propen-1-One, 2-Fluoro-1-(3-Methoxyphenyl)- (9Ci) is a specialized fluorinated α,β-unsaturated ketone, also known as a fluorinated chalcone derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the fluorine atom and the conjugated enone system, enabling precise molecular construction for high-value applications. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and materials science industries seeking to incorporate fluorinated motifs into novel molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) agents, anti-inflammatory compounds, and kinase inhibitors where fluorine substitution enhances metabolic stability and bioavailability.
• Agrochemical Research: Used in developing novel fluorinated pesticides and herbicides, leveraging the fluorine atom to improve lipophilicity, target binding, and environmental persistence of active ingredients.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic electronic materials, where the fluorinated aromatic structure can influence dielectric properties and thermal stability.
• Chemical Biology Probe: Employed in the design of activity-based probes and fluorescent tags for studying enzyme mechanisms and biological pathways, utilizing its reactive enone functionality for selective conjugation.
• Organic Synthesis Building Block: Utilized in Michael additions, cycloadditions, and other carbon-carbon bond-forming reactions to create complex, fluorinated heterocycles and natural product analogs.

Basic Information

Product Name	2-Propen-1-One, 2-Fluoro-1-(3-Methoxyphenyl)- (9Ci)
CAS No.	506437-44-1
Molecular Formula	C10H9FO2
Molecular Weight	180.18 g/mol
Synonyms	2-Fluoro-1-(3-methoxyphenyl)prop-2-en-1-one; 3'-Methoxy-2-fluorochalcone; 1-(3-Methoxyphenyl)-2-fluoroprop-2-en-1-one; 2-Fluoro-3'-methoxychalcone; (E)-2-Fluoro-1-(3-methoxyphenyl)prop-2-en-1-one; 2-Fluoro-1-(3-methoxyphenyl)-2-propen-1-one; Fluorinated chalcone derivative; α-Fluoro-3-methoxy chalcone
EINECS	Contact for details

Quality Control

Our 2-Propen-1-One, 2-Fluoro-1-(3-Methoxyphenyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to minimize degradation. Keep away from strong bases and fluorides. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.