Description

4-Nitrophenylboronic Acid Neopentylglycol Ester is a protected boronic acid derivative, a crucial intermediate in modern synthetic organic chemistry and pharmaceutical research. Its primary value lies in its enhanced stability compared to the free boronic acid, making it a superior reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require aryl-aryl bond formation.
• Material Science: Serves as a monomer or precursor in the creation of organic electronic materials, such as polymers for OLEDs or conductive films.
• Chemical Biology & Proteomics: Employed as a probe or linker in bioconjugation strategies and the development of enzyme inhibitors.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and catalysis research.
• Ligand Synthesis: Used as a precursor for creating sophisticated ligands in coordination chemistry and catalysis.

Basic Information

Product Name	4-Nitrophenylboronic Acid Neopentylglycol Ester
CAS No.	502622-85-7
Molecular Formula	C13H18BNO5
Molecular Weight	279.10 g/mol
Synonyms	2-(4-Nitrophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 4-Nitrophenylboronic Acid Pinanediol Ester (common misnomer); 4-Nitrobenzeneboronic Acid Neopentyl Glycol Ester; Neopentyl Glycol (4-Nitrophenyl)boronate; B-(4-Nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (related structure); PINACOL (4-NITROPHENYL)BORONATE; 4-NO2PhB(Nep); 4-Nitrophenyl-B(NPG)
EINECS	Contact for details

Quality Control

Our 4-Nitrophenylboronic Acid Neopentylglycol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.