Description

5-(2-Trifluoromethyl-Phenyl)-2H-Pyrazol-3-Ylamine is a high-purity, advanced pharmaceutical intermediate characterized by its pyrazole core and trifluoromethylphenyl substituent. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine chemistry. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug molecules, especially in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging the biological activity of the pyrazole and trifluoromethyl groups.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functional materials requiring fluorine-containing aromatic systems.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	5-(2-Trifluoromethyl-Phenyl)-2H-Pyrazol-3-Ylamine
CAS No.	502133-02-0
Molecular Formula	C10H8F3N3
Molecular Weight	227.19 g/mol
Synonyms	3-Amino-5-(2-(trifluoromethyl)phenyl)-1H-pyrazole; 5-(2-Trifluoromethylphenyl)-1H-pyrazol-3-amine; 1H-Pyrazol-3-amine, 5-[2-(trifluoromethyl)phenyl]-; 5-(α,α,α-Trifluoro-o-tolyl)-3-amino-1H-pyrazole; 3-Amino-5-(α,α,α-trifluoro-o-tolyl)pyrazole
EINECS	Contact for details

Quality Control

Our production of 5-(2-Trifluoromethyl-Phenyl)-2H-Pyrazol-3-Ylamine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality system is designed to support development and commercial scale requirements under ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.