Description

2-(1-Benzothiophen-5-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, catalyst development, and functional polymer synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing benzothiophene scaffolds.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by introducing the benzothiophene moiety into target molecules.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for electron-transport materials and emissive layer components in display and lighting technologies.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: A versatile reagent for Suzuki-Miyaura coupling to create biaryl and heterobiaryl structures with high efficiency and selectivity.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in medicinal chemistry and diagnostic assay development.

Basic Information

Product Name	2-(1-Benzothiophen-5-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	501945-71-7
Molecular Formula	C₁₄H₁₇BO₂S
Molecular Weight	260.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]thiophene; Benzo[b]thiophen-5-ylboronic acid pinacol ester; 5-Benzo[b]thienylboronic acid pinacol ester; 2-(Benzo[b]thiophen-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzothiophene; BTBP; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of 2-(1-Benzothiophen-5-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure compliance with exacting purity standards suitable for research and commercial scale applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture must be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.