Description

1-Fluoro-3-Iodonaphthalene is a high-purity, halogenated naphthalene derivative serving as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it an invaluable reagent for constructing complex molecules through cross-coupling reactions and functional group transformations. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the naphthalene core provides specific biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of organic semiconductors, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions due to the reactive iodine moiety.
• Fluorination Studies: Used as a model compound in methodological development for introducing fluorine atoms into complex aromatic systems.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for metal catalysis and organocatalysis.

Basic Information

Product Name	1-Fluoro-3-Iodonaphthalene
CAS No.	501433-11-0
Molecular Formula	C₁₀H₆FI
Molecular Weight	272.06 g/mol
Synonyms	3-Iodo-1-fluoronaphthalene; 1-Fluoro-3-iodonaphthalene; Naphthalene, 1-fluoro-3-iodo-; 1-Fluoronaphthalene-3-iodide; 3-Fluoro-1-iodonaphthalene (isomer); F-INaph; 1-F-3-I-Naph
EINECS	Contact for details

Quality Control

Every batch of 1-Fluoro-3-Iodonaphthalene is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.