Description

5,5-Dimethyl-2-[4-(Trifluoromethyl)Phenyl]-1,3,2-Dioxaborinane is a high-purity organoboron reagent, specifically a cyclic boronic ester, widely used in advanced synthetic chemistry. Its core value lies in enabling efficient and selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable building blocks for drug discovery and specialty chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic ester, crucial for synthesizing biaryl structures found in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Serves as a protected boronic acid precursor in the multi-step synthesis of drug candidates, particularly those containing trifluoromethylphenyl motifs for enhanced metabolic stability and lipophilicity.
• Agrochemical Research & Development: Used to create novel herbicides, fungicides, and insecticides by incorporating the 4-(trifluoromethyl)phenyl group into lead compounds.
• Materials Science & OLED Development: Acts as a monomer or building block for creating organic electronic materials, such as charge-transport layers or emissive materials in organic light-emitting diodes (OLEDs).
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands for transition metal catalysis or as a precursor for boron-containing catalysts.
• Chemical Biology & Probe Development: Useful for synthesizing boron-tagged molecules used as probes in bioimaging or for studying biological processes.

Basic Information

Product Name	5,5-Dimethyl-2-[4-(Trifluoromethyl)Phenyl]-1,3,2-Dioxaborinane
CAS No.	501374-30-7
Molecular Formula	C13H16BF3O2
Molecular Weight	272.07 g/mol
Synonyms	2-(4-(Trifluoromethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzotrifluoride; [4-(Trifluoromethyl)phenyl]boronic acid, 5,5-dimethyl-1,3,2-dioxaborinane ester; 5,5-Dimethyl-2-(4-trifluoromethylphenyl)-1,3,2-dioxaborinane; 4-(Trifluoromethyl)benzeneboronic acid cyclic ester with 2,2-dimethyl-1,3-propanediol; Pinacol Trifluoromethylphenylboronate (related analogue); 4-CF3-Ph-Bdan (common abbreviation in some literature)
EINECS	Contact for details

Quality Control

Our 5,5-Dimethyl-2-[4-(Trifluoromethyl)Phenyl]-1,3,2-Dioxaborinane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.