Description

1H-Indole-1-Carboxylic Acid, 2-Borono-6-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-, 1-(1,1-Dimethylethyl) Ester (9Ci) is a sophisticated, multi-functional organoboron building block designed for advanced synthetic chemistry. This compound is critical for enabling complex molecular construction, particularly in the synthesis of novel pharmaceutical intermediates and active ingredients. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as Suzuki-Miyaura cross-coupling reactions and the development of boron-containing drug candidates.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex indole-based molecules in drug discovery and development pipelines.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid ester reagent for forming carbon-carbon bonds, essential for creating complex organic architectures.
• Agrochemical Research: Used in the synthesis of novel active ingredients for crop protection and pest management.
• Material Science: Employed in the development of organic electronic materials and advanced polymers requiring specific indole or boron functionalities.
• Chemical Biology Probes: Utilized to create labeled compounds and probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Provides a protected and stable form of a reactive boronic acid group for robust manufacturing processes.

Basic Information

Item	Details
Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-6-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]-, 1-(1,1-Dimethylethyl) Ester (9Ci)
CAS No.	501364-51-8
Molecular Formula	C21H34BNO4Si
Molecular Weight	403.40 g/mol
Synonyms	2-Borono-6-((tert-butyldimethylsilyloxy)methyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-borono-6-(((tert-butyldimethylsilyl)oxy)methyl)-1H-indole-1-carboxylate; 1-(tert-Butoxycarbonyl)-6-(((tert-butyldimethylsilyl)oxy)methyl)-1H-indole-2-boronic acid; BOC-6-TBS-indole-2-boronic acid; 2-Borono-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data to support your research and development needs. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. Our quality systems are designed to meet the stringent requirements of pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.