Description

Boc-(R)-3-Amino-3-(1-Naphthyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a bulky naphthyl side chain, protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of sterically demanding, aromatic functionalities. It is primarily utilized by pharmaceutical R&D and process chemistry teams in the development of novel active pharmaceutical ingredients (APIs), especially for targeted therapies and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of constrained peptides and bioactive molecules.
• Peptidomimetic Drug Discovery: Used to incorporate rigid, hydrophobic motifs into peptide backbones to enhance metabolic stability and receptor binding affinity.
• API Development: Serves as a building block in the research and scale-up manufacturing of potential new drug candidates.
• Asymmetric Synthesis: Employed in academic and industrial research for studying asymmetric catalysis and creating chiral compound libraries.
• Bioconjugation: The protected amino acid can be used to create specialized linkers or modifiers for proteins and other biomolecules.

Basic Information

Product Name	Boc-(R)-3-Amino-3-(1-Naphthyl)-Propionic Acid
CAS No.	500789-00-4
Molecular Formula	C₁₈H₂₁NO₄
Molecular Weight	315.36 g/mol
Synonyms	(R)-3-((tert-Butoxycarbonyl)amino)-3-(naphthalen-1-yl)propanoic acid; Boc-D-1-Nal-OH; Boc-(R)-3-Amino-3-(1-naphthyl)propanoic acid; (R)-2-((tert-Butoxycarbonyl)amino)-2-(1-naphthyl)acetic acid, β-homo derivative; tert-Butyl (R)-(1-carboxy-2-(naphthalen-1-yl)ethyl)carbamate; N-Boc-3-amino-3-(1-naphthyl)propionic acid; Boc-1-Nal-OH (D-form); Boc-D-β-homo-1-naphthylalanine
EINECS	Contact for details

Quality Control

Our Boc-(R)-3-Amino-3-(1-Naphthyl)-Propionic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.