Description

Butanedioic Acid, 2-Iodo-3-Methyl-, 1-Ethyl 4-Methyl Ester, (2R,3S)-Rel- (9Ci) CAS NO 500137-36-0 is a high-purity, stereochemically defined iodo-succinate derivative, serving as a critical chiral building block and advanced synthetic intermediate. Its value lies in enabling precise molecular construction for complex organic synthesis, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-fidelity intermediates for asymmetric synthesis and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, including potential enzyme inhibitors and receptor modulators.
• Asymmetric Synthesis: Utilized in stereoselective carbon-carbon and carbon-heteroatom bond-forming reactions to construct complex molecular architectures.
• Agrochemical Research: Serves as a precursor in the synthesis of chiral active ingredients for crop protection products.
• Ligand and Catalyst Development: Used in the preparation of novel chiral ligands and organocatalysts for catalytic asymmetric transformations.
• Fine Chemical Production: Intermediate for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Butanedioic Acid, 2-Iodo-3-Methyl-, 1-Ethyl 4-Methyl Ester, (2R,3S)-Rel- (9Ci)
CAS No.	500137-36-0
Molecular Formula	C8H13IO4
Molecular Weight	300.09 g/mol
Synonyms	(2R,3S)-rel-2-Iodo-3-methylsuccinic acid 1-ethyl 4-methyl ester; 1-Ethyl 4-methyl (2R,3S)-rel-2-iodo-3-methylbutanedioate; rel-(2R,3S)-2-Iodo-3-methylsuccinic Acid Ethyl Methyl Ester; Ethyl Methyl (2R,3S)-rel-2-Iodo-3-methylsuccinate; 2-Iodo-3-methylsuccinic Acid 1-Ethyl 4-Methyl Ester (rel-(2R,3S)-form); Butanedioic acid, 2-iodo-3-methyl-, 1-ethyl 4-methyl ester, (2R,3S)-rel- CAS 500137-36-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Identity, purity, and stereochemical integrity are confirmed through a suite of analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; containers should be kept tightly sealed under an inert atmosphere when not in use. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (rel-(2R,3S))
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.