Description

Boc-L-Proline-Methyl Ester CAS NO 59936-29-7 is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for applications such as peptide synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key intermediate for the solid-phase and solution-phase synthesis of peptides and peptidomimetics, particularly those containing proline residues.
• Pharmaceutical Intermediates: Used in the research and production of novel drug candidates, including protease inhibitors and other biologically active compounds.
• Chiral Auxiliary & Catalyst Preparation: Employed in the synthesis of chiral catalysts and auxiliaries for asymmetric synthesis.
• Bioconjugation & Labeling: Acts as a precursor for creating labeled peptides or protein conjugates used in diagnostic and biochemical research.
• Combinatorial Chemistry: A valuable building block in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Academic & Industrial R&D: Fundamental reagent for methodological development in organic chemistry and medicinal chemistry research.

Basic Information

Product Name	Boc-L-Proline-Methyl Ester
CAS No.	59936-29-7
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester; Methyl (S)-1-[(1,1-dimethylethoxy)carbonyl]-2-pyrrolidinecarboxylate; Boc-L-Pro-OMe; Boc-Pro-OMe; N-Boc-L-proline methyl ester; N-tert-Butoxycarbonyl-L-proline methyl ester; L-Proline, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Methyl N-Boc-L-prolinate
EINECS	Contact for details

Quality Control

Our Boc-L-Proline-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and optical rotation measurement, to ensure high chemical and chiral purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-60° to -65° (c=1 in CHCl₃)
Chiral Purity (HPLC)	≥99.0%
Melting Point	40-45°C
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.