Description

8-Chlororugulovasine B is a synthetic derivative of the ergot alkaloid scaffold, specifically a halogenated rugulovasine analog. This compound is of significant interest in advanced pharmaceutical research and development due to its potential as a key intermediate or a novel pharmacophore. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of new therapeutic agents, particularly those targeting neurological and cardiovascular pathways. The precise chemical modification offered by the 8-chloro substitution makes it a valuable tool for structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel ergot-based drug candidates.
• Biochemical Research: Used as a reference standard or probe in studies investigating serotonin (5-HT) and dopamine receptor interactions.
• Medicinal Chemistry: A key substrate for the development and optimization of compounds with potential antipsychotic, anti-migraine, or vasoconstrictive properties.
• Academic Research: Employed in university and institutional labs for studying the biosynthesis, metabolism, and biological activity of complex alkaloids.
• High-Throughput Screening (HTS): Can be incorporated into compound libraries for screening against various biological targets.
• Process Chemistry Development: Used to develop and scale up synthetic routes for complex heterocyclic compounds.

Basic Information

Product Name	8-Chlororugulovasine B
CAS No.	59787-46-1
Molecular Formula	C₁₆H₁₇ClN₂O₂
Molecular Weight	304.77 g/mol
Synonyms	8-Chloro-rugulovasine B; 8-Chloro-10α-methoxy-6-methyl-6,7-secoergoline-8-carboxylic acid 6,7-lactam; 8-Chloro-10α-methoxy-6-methyl-6,7-secoergoline-8-carboxylic acid lactam; 8-Chloro-10-methoxy-6-methyl-6,7-secoergoline-8-carboxylic acid 6,7-lactam; 8-Cl-Rugulovasine B
EINECS	Contact for details

Quality Control

Our 8-Chlororugulovasine B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for fine chemical synthesis, and specifications can be aligned with client requirements for advanced R&D use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under inert atmosphere if prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.