Description

Ethyl 2-Diazo-3,3,3-Trifluoro-Propionate is a versatile and highly reactive diazo compound, valued for its role as a key trifluoromethyl building block in advanced organic synthesis. Its primary commercial importance lies in enabling the efficient introduction of the trifluoromethyl group, a critical moiety for modulating the biological activity and physicochemical properties of target molecules. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for incorporating the trifluoromethyl group to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Catalyst & Ligand Development: Serves as a building block for creating specialized catalysts and ligands used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials with unique properties.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and tags for studying biological systems and drug-target interactions.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic chemistry, enabling novel C-C and C-H bond functionalization strategies.

Basic Information

Product Name	Ethyl 2-Diazo-3,3,3-Trifluoro-Propionate
CAS No.	59733-95-8
Molecular Formula	C5H5F3N2O2
Molecular Weight	182.10 g/mol
Synonyms	Ethyl 2-Diazo-3,3,3-Trifluoropropionate; 2-Diazo-3,3,3-trifluoropropionic Acid Ethyl Ester; Ethyl 2-Diazo-3,3,3-Trifluoropropanoate; 3,3,3-Trifluoro-2-diazopropionic Acid Ethyl Ester; Ethyl α-Diazo-β,β,β-Trifluoropropionate; Ethyl Trifluoromethyl Diazoacetate; TFDAE; EDFP
EINECS	Contact for details

Quality Control

Our Ethyl 2-Diazo-3,3,3-Trifluoro-Propionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our commitment to quality supports applications in GMP and research-grade synthesis, ensuring reliability for your most demanding projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at recommended temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or ambient temperature should be avoided to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.