Description

4-Nitrophenyl-2-Diazo-3,3,3-Trifluoropropionate is a specialized diazo compound and trifluoromethylated building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a photoreactive diazo group and a trifluoromethyl moiety, makes it a valuable precursor for introducing fluorinated groups into target molecules under mild conditions. This high-value intermediate is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry for lead optimization.
• Agrochemical Research: Used in developing novel pesticides and herbicides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Precursor for creating fluorinated polymers, coatings, and specialty materials with unique surface properties.
• Photoaffinity Labeling: The diazo group allows its use in biochemical research as a photoactivatable cross-linking agent for studying protein-ligand interactions.
• Organic Synthesis Reagent: Employed in C-H functionalization and cyclopropanation reactions to construct complex, fluorinated molecular architectures.
• Liquid Crystal & OLED Material Development: Serves as a fluorinated synthon for electronic materials requiring specific dielectric and optical properties.

Basic Information

Product Name	4-Nitrophenyl-2-Diazo-3,3,3-Trifluoropropionate
CAS No.	59733-94-7
Molecular Formula	C9H4F3N3O4
Molecular Weight	275.14 g/mol
Synonyms	2-Diazo-3,3,3-trifluoro-1-(4-nitrophenoxy)-1-propanone; 4-Nitrophenyl Diazo(trifluoroacetate); p-Nitrophenyl 2-Diazo-3,3,3-trifluoropropionate; 2-Diazo-3,3,3-trifluoropropionic Acid 4-Nitrophenyl Ester; α-Diazo-α-trifluoroacet-p-nitrophenol; Trifluoromethyl Diazoketone p-Nitrophenyl Ester
EINECS	Contact for details

Quality Control

Our production of 4-Nitrophenyl-2-Diazo-3,3,3-Trifluoropropionate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and decomposition. Keep away from heat, sparks, and open flame. This material is light-sensitive and easily oxidized.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Melting Point	Contact for details
Water Content (KF)	< 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.