Description

3,3,3-Trifluoro-2-diazopropionyl chloride is a highly reactive and versatile fluorinated diazo compound used as a key building block in advanced organic synthesis. Its unique structure, featuring both a diazo group and an acid chloride, makes it an essential reagent for introducing the trifluoromethyl-diazo moiety into target molecules. This compound is particularly valuable for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients. Please inquire for specific grades and packaging options.

Application

• Pharmaceutical Intermediate: A critical precursor for the synthesis of trifluoromethyl-substituted heterocycles and complex bioactive molecules, enabling the exploration of new drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialty polymers and advanced materials with unique fluorinated properties.
• Organic Synthesis Reagent: Employed in cyclopropanation reactions, [2+1] cycloadditions, and other transformations to construct complex, fluorinated molecular architectures.
• Fluorine Chemistry: An important tool for medicinal and synthetic chemists focused on incorporating fluorine atoms to modulate the lipophilicity, metabolic stability, and binding affinity of compounds.

Basic Information

Product Name	3,3,3-Trifluoro-2-diazopropionyl chloride
CAS No.	59733-92-5
Molecular Formula	C3HF3ClN2O
Molecular Weight	188.50 g/mol
Synonyms	2-Diazo-3,3,3-trifluoropropionyl chloride; 3,3,3-Trifluoro-2-diazopropanoyl chloride; Trifluorodiazoacetyl chloride; α-Diazo-β,β,β-trifluoropropionyl chloride; 2-Diazo-1,1,1-trifluoropropan-1-one; TFDPC; 2,2,2-Trifluoro-1-diazoethanone hydrochloride (incorrect but common misnomer)
EINECS	Contact for details

Quality Control

Our 3,3,3-Trifluoro-2-diazopropionyl chloride is manufactured under strict quality protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Yellow to orange liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.