Description

1-Bromo-2-Chloro-4,5-Difluorobenzene is a high-purity halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its precise substitution pattern makes it an invaluable intermediate for constructing complex molecules with specific electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, improving device performance.
• Polymer Chemistry: Monomer for synthesizing specialty polymers and engineering plastics with enhanced thermal stability and chemical resistance.
• Cross-Coupling Reactions: Essential substrate in Suzuki, Stille, and Buchwald-Hartwig amination reactions for creating complex biaryl structures.
• Chemical Research & Development: Versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel fluorinated compounds.

Basic Information

Product Name	1-Bromo-2-Chloro-4,5-Difluorobenzene
CAS No.	59447-06-2
Molecular Formula	C6H2BrClF2
Molecular Weight	227.44 g/mol
Synonyms	2-Bromo-1-Chloro-4,5-Difluorobenzene; 4,5-Difluoro-1-Bromo-2-Chlorobenzene; 1-Chloro-2-Bromo-4,5-Difluorobenzene; Benzene, 1-bromo-2-chloro-4,5-difluoro-; 59447-06-2; B2C4,5DFB (abbrev.)
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-4,5-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee consistent quality and traceability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	45 - 50 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.