Description

2-Formyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a versatile and highly functionalized pyrrolidine derivative, serving as a crucial chiral building block in modern organic synthesis. Its value lies in the orthogonal protection of the pyrrolidine nitrogen and the reactive formyl group, enabling precise, multi-step synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of pyrrolidine-based drug candidates, including protease inhibitors and neurological agents.
• Peptidomimetics & Constrained Peptides: Used to introduce conformationally restricted proline analogs into peptide backbones to enhance stability and biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands and organocatalysts.
• Agrochemical Synthesis: Employed in the research and production of advanced pesticides and herbicides with specific stereochemical requirements.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Custom Synthesis Projects: Used as a bespoke building block for contract research organizations (CROs) and CDMOs serving the life sciences sector.

Basic Information

Product Name	2-Formyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	59378-82-4
Molecular Formula	C10H17NO3
Molecular Weight	199.25 g/mol
Synonyms	1-Boc-2-formylpyrrolidine; N-Boc-2-formylpyrrolidine; tert-Butyl 2-formylpyrrolidine-1-carboxylate; 2-Formyl-1-(tert-butoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2-formylpyrrolidine; Pyrrolidine-1-carboxylic acid, 2-formyl-, 1,1-dimethylethyl ester; Boc-2-CHO-Pro; (S)- or (R)- enantiomers may be specified.
EINECS	Contact for details

Quality Control

Our 2-Formyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.