Description

Erythromycin A Dihydrate is a high-purity, crystalline dihydrate form of the macrolide antibiotic Erythromycin A. This compound is a critical active pharmaceutical ingredient (API) and a key intermediate in the synthesis of various semi-synthetic antibiotics. It is essential for manufacturers in the pharmaceutical and veterinary medicine industries requiring a reliable source of a well-characterized antibiotic base material for formulation and further chemical modification.

Application

• Active Pharmaceutical Ingredient (API) for the production of oral and topical antibiotic formulations.
• Chemical Intermediate in the synthesis of advanced macrolide antibiotics like Clarithromycin and Azithromycin.
• Veterinary Pharmaceutical production for treating bacterial infections in livestock and companion animals.
• Reference Standard for quality control and analytical testing in pharmaceutical laboratories.
• Research & Development of new antimicrobial agents and drug delivery systems.
• Biochemical Research as a tool for studying protein synthesis inhibition in bacterial ribosomes.

Basic Information

Item	Detail
Product Name	Erythromycin A Dihydrate
CAS No.	59319-72-1
Molecular Formula	C37H67NO13 • 2H2O
Molecular Weight	749.95 g/mol (for the dihydrate)
Synonyms	Erythromycin A Dihydrate; Erythromycin A Hydrate; Erythromycin Dihydrate; (3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione Dihydrate; Erythromycin Base Dihydrate; Abomacetin Dihydrate
EINECS	Contact for details

Quality Control

Our Erythromycin A Dihydrate is manufactured and tested under a strict quality management system. Each batch is analyzed to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay, related substances, water content, and identification. We can supply material compliant with various pharmacopeial monographs, including USP and EP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in its original packaging or a suitable moisture-proof container to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water (Karl Fischer)	4.0% - 6.5%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.