Description

1-Bromo-5-Chloro-2-Methoxy-3-Methylbenzene is a high-purity halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecular architectures in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogen and methoxy groups for bioactivity.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and advanced polymers requiring specific aromatic frameworks.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination due to the reactive bromine substituent.
• Dye and Pigment Intermediate: Used in the synthesis of specialized dyes and pigments where the chloro and methoxy groups influence color and stability.

Basic Information

Product Name	1-Bromo-5-Chloro-2-Methoxy-3-Methylbenzene
CAS No.	59106-55-7
Molecular Formula	C8H8BrClO
Molecular Weight	235.51 g/mol
Synonyms	2-Bromo-4-Chloro-6-Methoxytoluene; 3-Methyl-6-Bromo-4-Chloroanisole; 5-Chloro-2-Methoxy-3-Methylbromobenzene; 4-Chloro-2-Methoxy-6-methyl-1-bromobenzene; 1-Bromo-5-chloro-2-methoxy-3-methyl-benzene; Benzene, 1-bromo-5-chloro-2-methoxy-3-methyl-; 2-Methoxy-6-methyl-4-chlorobromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Chloro-2-Methoxy-3-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures batch-to-batch consistency, meeting the stringent requirements of research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.