Description

8-Hydroxyhyperforin 8,1-Hemiacetal is a specialized derivative of hyperforin, a key bioactive constituent of St. John's wort (*Hypericum perforatum*). This compound is of significant interest for its role in advanced pharmaceutical research and development, particularly in the study of natural product derivatives and their biological activities. It is primarily utilized by research institutions, pharmaceutical R&D departments, and manufacturers of high-purity reference standards and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control of herbal extracts and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the research and synthesis of novel pharmaceutical compounds targeting neurological and mood-related disorders.
• Biochemical Research: Employed in *in vitro* and *in vivo* studies to investigate the pharmacological mechanisms, metabolism, and structure-activity relationships (SAR) of hyperforin analogs.
• Nutraceutical Development: Acts as a marker compound for the standardization and potency assessment of high-end St. John's wort extracts in dietary supplement formulations.
• Academic Research: A key reagent for universities and research institutes studying natural product chemistry, phytochemistry, and medicinal plant biosynthesis pathways.

Basic Information

Product Name	8-Hydroxyhyperforin 8,1-Hemiacetal
CAS No.	59014-02-7
Molecular Formula	C35H52O5
Molecular Weight	552.79 g/mol
Synonyms	8-Hydroxyhyperforin Hemiacetal; Hyperforin Derivative; 8-Hydroxy-hyperforin-8,1-hemiacetal; (1R,5S,7R,8S)-8-Hydroxy-4,4,7-trimethyl-3-methylidene-2,9-dioxatricyclo[7.3.1.01,5]tridecane-4,10,13-trione (and related IUPAC names); St. John's Wort Derivative
EINECS	Contact for details

Quality Control

Every batch of 8-Hydroxyhyperforin 8,1-Hemiacetal is manufactured and analyzed under strict quality management systems. We employ advanced chromatographic techniques (HPLC, GC) and spectroscopic methods (NMR, MS) to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.