Description

Difluoromethylsulfenylchloride is a specialized organosulfur and organofluorine reagent used as a key building block in advanced synthetic chemistry. Its primary value lies in its ability to introduce the difluoromethylthio (-SCF2H) group, a moiety of significant interest in medicinal chemistry and agrochemical development for modulating physicochemical properties. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel compounds with enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs) containing the difluoromethylthioether group, which can improve drug-like properties.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the SCF2H group contributes to biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or modifying agent for advanced polymers and functional materials with specific surface properties.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and the synthesis of complex fluorinated molecules.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.

Basic Information

Item	Details
Product Name	Difluoromethylsulfenylchloride
CAS No.	58932-27-7
Molecular Formula	CHClF2S
Molecular Weight	118.53 g/mol
Synonyms	Chlorodifluoromethyl Sulfide; Difluoromethylsulfenyl Chloride; S-(Chlorodifluoromethyl) Thioate; Thiocarbonyl Chloride, Difluoro-; Difluoromethyl Thiochloroformate; SCF2Cl; (Chlorodifluoromethyl)sulfane
EINECS	Contact for details

Quality Control

Our Difluoromethylsulfenylchloride is produced under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by GC or NMR), identity confirmation, and impurity profiles. Our quality system is designed to meet the stringent requirements of process chemistry and regulatory starting material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place. Due to its hygroscopic and strong acid/organic solvent nature, it is recommended to handle and store under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.