Description

2-Formyl-5-(Trifluoromethyl)Phenol, 4-Formyl-3-Hydroxybenzotrifluoride, 4-(Trifluoromethyl)Salicylaldehyde CAS NO 58914-34-4 is a versatile trifluoromethylated aromatic aldehyde that serves as a critical building block in advanced organic synthesis. Its unique structure, combining a formyl group with a phenolic hydroxyl and a trifluoromethyl substituent, makes it a high-value intermediate for creating complex molecules with enhanced properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine chemistry for improved bioactivity, metabolic stability, and material performance.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and insecticides, with the CF3 group contributing to enhanced pesticidal activity, rainfastness, and selective action.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel chelating ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Monomer: Employed in the production of specialty polymers, liquid crystals, and organic electronic materials, where its structure imparts specific thermal, optical, and electronic properties.
• Fluorescent Probe and Dye Synthesis: Acts as a core scaffold for creating advanced fluorescent markers, molecular sensors, and high-performance dyes used in bioimaging and analytical chemistry.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl and conjugated systems.

Basic Information

Item	Details
Product Name	2-Formyl-5-(Trifluoromethyl)Phenol / 4-Formyl-3-Hydroxybenzotrifluoride
CAS No.	58914-34-4
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	4-(Trifluoromethyl)Salicylaldehyde; 5-(Trifluoromethyl)Salicylaldehyde; 2-Hydroxy-5-(trifluoromethyl)benzaldehyde; 3-Hydroxy-4-(trifluoromethyl)benzaldehyde; 4-Formyl-2-hydroxybenzotrifluoride; 2-Formyl-4-(trifluoromethyl)phenol; 5-Trifluoromethylsalicylaldehyde; 58914-34-4
EINECS	Contact for details

Quality Control

Our 2-Formyl-5-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with major regulatory frameworks, including REACH, and can tailor quality protocols to meet specific customer or pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and stability. Keep away from strong oxidizing agents, strong bases, and sources of heat.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.