Description

tert-Butylchlorodiphenylsilane is a highly versatile organosilicon reagent, specifically a chlorosilane, widely recognized for its role as a robust protecting group agent in complex organic synthesis. Its primary value lies in its ability to selectively protect hydroxyl groups, offering superior stability under a wide range of reaction conditions compared to other silylating agents. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over synthetic pathways.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the protection of alcohol and phenol functionalities during the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the manufacture of complex pesticide and herbicide molecules where selective protection is required.
• Natural Product & Peptide Chemistry: Employed in the synthesis of sensitive natural compounds and peptides to prevent unwanted side reactions.
• Material Science Research: Serves as a precursor or surface modifying agent in the development of silicon-based polymers and advanced hybrid materials.
• Academic & Industrial R&D: A staple reagent in laboratory settings for method development and exploratory synthesis across organic chemistry.

Basic Information

Product Name	tert-Butylchlorodiphenylsilane
CAS No.	58479-61-1
Molecular Formula	C16H19ClSi
Molecular Weight	274.86 g/mol
Synonyms	tert-Butyldiphenylsilyl Chloride; TBDPS-Cl; Chloro(tert-butyl)diphenylsilane; t-Butyldiphenylchlorosilane; Diphenyl-tert-butylsilyl Chloride; tert-Butylchloro(diphenyl)silane; 1,1-Dimethylethylchlorodiphenylsilane; (tert-Butyl)diphenylsilyl Chloride
EINECS	261-311-9

Quality Control

Our tert-Butylchlorodiphenylsilane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC or HPLC, identity confirmation (IR, NMR), and impurity profiling to ensure high chemical purity and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance with rigorous R&D and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts with water; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.