Description

2-Trimethylsiloxy-[1,3,2]-Dioxaphospholane is a specialized organosilicon-protected cyclic phosphite reagent. This compound is a critical intermediate in the synthesis of complex organophosphorus compounds and is valued for its role in protecting phosphate groups during sensitive chemical transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing nucleotide analogs, phosphoramidites, and other high-value fine chemicals.

Application

• Phosphoramidite Synthesis: A key protected intermediate in the automated solid-phase synthesis of oligonucleotides (DNA/RNA) for therapeutic and diagnostic applications.
• Nucleotide Chemistry: Used in the preparation of modified nucleosides and nucleotides for antiviral and anticancer drug discovery.
• Catalyst & Ligand Preparation: Serves as a precursor for chiral phosphite ligands used in asymmetric hydrogenation and other catalytic processes.
• Polymer Chemistry: Employed in the synthesis of phosphorus-containing polymers and flame retardants with tailored properties.
• Chemical Research: A versatile building block for introducing protected phosphate functionalities in complex molecule synthesis.

Basic Information

Product Name	2-Trimethylsiloxy-[1,3,2]-Dioxaphospholane
CAS No.	58068-62-5
Molecular Formula	C5H13O3PSi
Molecular Weight	180.22 g/mol
Synonyms	2-(Trimethylsilyloxy)-1,3,2-dioxaphospholane; 2-(Trimethylsiloxy)-1,3,2-dioxaphospholane; 2-Trimethylsiloxy-1,3,2-dioxaphospholane; 2-(Trimethylsilyloxy)-2H-1,3,2-dioxaphospholane; TMS-DOP; Cyclic TMS Phosphite; 1,3,2-Dioxaphospholane, 2-(trimethylsilyloxy)-; Phosphorous acid, P-[2-(trimethylsilyloxy)ethyl] ester, cyclic
EINECS	Contact for details

Quality Control

Our production of 2-Trimethylsiloxy-[1,3,2]-Dioxaphospholane adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized by NMR (1H, 13C, 31P), GC, and HPLC analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and potentially moisture-sensitive nature. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.