Description

4,4,4-Trifluoro-1-(3-Nitrophenyl)Butane-1,3-Dione is a specialized fluorinated diketone building block with a unique trifluoromethyl and nitro-substituted aromatic structure. This compound matters for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its fluorine atoms can impart desirable properties like metabolic stability and enhanced lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a chelating agent or precursor for β-diketone ligands used in coordination chemistry and catalysis.
• Advanced Material Research: Employed in the creation of fluorinated polymers and organic electronic materials for improved thermal and chemical stability.
• Chemical Research & Development: A versatile building block for exploring new reactions in organofluorine chemistry and synthesizing complex heterocycles.

Basic Information

Product Name	4,4,4-Trifluoro-1-(3-Nitrophenyl)Butane-1,3-Dione
CAS No.	57965-20-5
Molecular Formula	C10H6F3NO4
Molecular Weight	261.16 g/mol
Synonyms	1-(3-Nitrophenyl)-4,4,4-trifluorobutane-1,3-dione; 3'-Nitro-4,4,4-trifluoro-1-phenylbutane-1,3-dione; 4,4,4-Trifluoro-1-(3-nitrophenyl)-1,3-butanedione; 3-Nitrophenyl trifluoroacetylacetone; 1,3-Butanedione, 4,4,4-trifluoro-1-(3-nitrophenyl)-; TFND
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-1-(3-Nitrophenyl)Butane-1,3-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.