Description

(2S,4S,5R)-(-)-2-Chloro-3,4-Di-Me-5-Ph-1,3,2-Oxazaphospholidine 2-Sulfide is a high-purity, stereochemically defined organophosphorus compound, serving as a critical chiral intermediate and ligand in asymmetric synthesis. Its precise stereochemistry makes it invaluable for inducing enantioselectivity in catalytic reactions, particularly in the synthesis of complex pharmaceutical molecules and agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality chiral building blocks.

Application

• Chiral Ligand in Asymmetric Catalysis: Employed as a key ligand for transition metal catalysts in enantioselective hydrogenation, hydroformylation, and cross-coupling reactions.
• Pharmaceutical Intermediate: Used in the stereoselective synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and infectious diseases.
• Agrochemical Synthesis: Serves as a precursor for the development of enantiomerically pure herbicides, fungicides, and insecticides.
• Methodology Development: A valuable tool in academic and industrial research for developing new asymmetric synthetic methodologies.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances where optical purity is critical.
• Polymer Science: Can be utilized to introduce chiral centers into polymers for advanced material applications.

Basic Information

Item	Information
Product Name	(2S,4S,5R)-(-)-2-Chloro-3,4-Di-Me-5-Ph-1,3,2-Oxazaphospholidine 2-Sulfide
CAS No.	57651-34-0
Molecular Formula	C11H15ClNOPS
Molecular Weight	275.73 g/mol
Synonyms	(-)-2-Chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide; (2S,4S,5R)-2-Chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-sulfide; (S,S,R)-2-Chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide; Chiral oxazaphospholidine sulfide; P-Chloro oxazaphospholidine sulfide ligand; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (2S,4S,5R)-(-)-2-Chloro-3,4-Di-Me-5-Ph-1,3,2-Oxazaphospholidine 2-Sulfide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, chiral GC, NMR, and mass spectrometry to confirm identity, enantiomeric excess, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.