Description

5-Fluoro-2,3-Dihydro-1H-Isoindole is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a fused benzene ring and a saturated pyrrole moiety with a fluorine substituent, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials. Its utility stems from the ability to introduce the pharmacologically favorable fluorine atom and the reactive secondary amine into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of potential drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the fluorinated isoindole scaffold can enhance biological activity and stability.
• Ligand and Catalyst Development: Acts as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, fluorinated polymers, and advanced dyes with tailored electronic properties.
• Chemical Biology Probes: Utilized to develop fluorescent tags or molecular probes for studying biological processes.
• Academic & R&D: A fundamental reagent for methodological studies in organic chemistry, especially in fluorination and heterocycle chemistry.

Basic Information

Product Name	5-Fluoro-2,3-Dihydro-1H-Isoindole
CAS No.	57584-71-1
Molecular Formula	C8H8FN
Molecular Weight	137.15 g/mol
Synonyms	5-Fluoro-2,3-dihydro-1H-isoindole; 5-Fluoroisoindoline; 1H-Isoindole, 5-fluoro-2,3-dihydro-; 5-Fluoro-1H-isoindoline; 5-Fluoro-2,3-dihydroisoindole; 5-Fluoro-isoindoline; 5-Fluoroisoindoline; 5-Fluoro-2,3-dihydro-1H-indene-1-amine (tautomeric form).
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2,3-Dihydro-1H-Isoindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard grades meet the stringent requirements for research and process development use, and we can support custom synthesis under cGMP guidelines for advanced clinical-stage projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.