Description

Resiniferatoxin CAS NO 57444-62-9 is a highly potent, naturally occurring capsaicin analog and transient receptor potential vanilloid 1 (TRPV1) agonist. This compound is of significant interest for its powerful pharmacological activity, which is several orders of magnitude greater than capsaicin. It is primarily utilized in advanced life science research and pharmaceutical development, particularly in the study of pain pathways, neurobiology, and as a potential tool for targeted neuronal ablation.

Application

• Neuroscience Research: A critical tool for studying pain sensation, neurogenic inflammation, and the role of TRPV1 receptors in neuronal signaling and desensitization.
• Pharmacological Studies: Used in high-throughput screening and the development of novel analgesic and anti-inflammatory agents targeting the TRPV1 pathway.
• Preclinical Models: Employed to create animal models of chronic pain and to investigate mechanisms of nociception and hyperalgesia.
• Cell Biology: Applied in studies of calcium influx and cellular responses mediated by TRPV1 receptor activation in specific cell lines.
• Potential Therapeutic Agent: Investigated for its use in targeted ablation of pain-sensing neurons, offering a potential approach for managing intractable pain conditions.
• Biochemical Reagent: Serves as a standard and reference compound in analytical and bioassay laboratories for quality control and method validation.

Basic Information

Product Name	Resiniferatoxin
CAS No.	57444-62-9
Molecular Formula	C37H40O9
Molecular Weight	628.71 g/mol
Synonyms	Resiniferatoxin; RTX; (6S,7R,14R,15R)-16-(4-Hydroxy-3-methoxyphenyl)-14-methyl-4,15-bis(3-methylbut-2-en-1-yl)-11-oxo-5,8,17-trioxatetracyclo[10.6.1.01,10.02,7]nonadeca-2(7),3,9,18-tetraen-6-yl (2E,4E,6E,8E)-10-(4-Hydroxy-3-methoxyphenyl)-10-oxodeca-2,4,6,8-tetraenoate; Euphorbia resinifera toxin; Resiniferonol 9,13,14-orthophenylacetate 20-(4-hydroxy-3-methoxyphenyl)acetate; NSC 393506
EINECS	Contact for details

Quality Control

Our Resiniferatoxin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals to support the integrity of your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere or with desiccant to prevent moisture uptake. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.