Description

Resiniferonol is a potent diterpene natural product, a key intermediate in the synthesis of resiniferatoxin and related ultra-potent capsaicin analogs. Its unique chemical scaffold makes it a critical building block for advanced pharmaceutical research and development, particularly in the study of pain pathways and neurobiology. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors, enabling the creation of next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Primary precursor in the multi-step synthesis of resiniferatoxin (RTX), an ultra-potent TRPV1 agonist.
• Neuroscience Research: Used to develop novel chemical tools and probes for studying vanilloid receptor (TRPV1) function and pain signal transduction.
• Analgesic Drug Development: Serves as a core structure for creating new classes of non-opioid pain management candidates with targeted action.
• Chemical Biology: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of capsaicinoid analogs.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for the identification and quantification of related compounds.
• Fine Chemical Synthesis: A valuable chiral starting material for the synthesis of complex natural products and diterpenoid derivatives.

Basic Information

Product Name	Resiniferonol
CAS No.	57444-60-7
Molecular Formula	C20H28O5
Molecular Weight	348.44 g/mol
Synonyms	Resiniferonol; (5S,6S,7S,9R,10S,12S)-6-Hydroxy-7-(hydroxymethyl)-10-methyl-4-methylidene-13-oxatetracyclo[8.5.0.05,9.012,16]pentadecane-8,11,15-trione; 12-Deoxyphorbol-13-(2-methylbutyrate); 12-Deoxyphorbol 13-(2-methylbutanoate); RTX Intermediate; Resiniferatoxin Precursor
EINECS	Contact for details

Quality Control

Our Resiniferonol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.