Description

n-[24-Oxo-3α,7α,12α-Tris(Trimethylsiloxy)-5β-Cholan-24-Yl]Glycine Methyl Ester is a key synthetic intermediate in the production of bile acid derivatives and other high-value steroidal compounds. Its primary value lies in its protected functional groups, which enable precise and efficient downstream chemical transformations in complex organic syntheses. This compound is essential for research and development laboratories, as well as production facilities, in the pharmaceutical and fine chemical sectors, particularly those focused on developing novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of modified bile acids and steroidal drug candidates targeting liver and metabolic disorders.
• Research Chemical: Used in academic and industrial R&D for studying bile acid metabolism, receptor interactions, and signaling pathways.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex molecular architectures with specific stereochemistry.
• Bioconjugate Development: Potential use in creating steroidal probes or carriers for targeted drug delivery systems.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	n-[24-Oxo-3α,7α,12α-Tris(Trimethylsiloxy)-5β-Cholan-24-Yl]Glycine Methyl Ester
CAS No.	57326-16-6
Molecular Formula	C36H67NO7Si3
Molecular Weight	710.19 g/mol
Synonyms	Glycine, N-[24-oxo-3α,7α,12α-tris(trimethylsiloxy)-5β-cholan-24-yl]-, methyl ester; Methyl N-[24-oxo-3α,7α,12α-tris(trimethylsiloxy)-5β-cholan-24-yl]glycinate; 3α,7α,12α-Tris-O-(trimethylsilyl)-5β-cholan-24-oic acid 24-(N-methoxycarbonylmethyl)amide; TMS-protected Cholylglycine Methyl Ester; 5β-Cholan-24-oic acid, 24-[[(methoxycarbonyl)methyl]amino]-3α,7α,12α-tris(trimethylsiloxy)-, (24R)-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our n-[24-Oxo-3α,7α,12α-Tris(Trimethylsiloxy)-5β-Cholan-24-Yl]Glycine Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.