Description

(1R)-1-(4-Methoxyphenyl)-2-(Methylamino)Ethanol CAS NO 57286-93-8 is a high-purity chiral intermediate of significant importance in pharmaceutical synthesis. This compound matters because it serves as a critical building block for the production of active pharmaceutical ingredients (APIs), particularly in adrenergic and cardiovascular drug classes. Pharmaceutical manufacturers and advanced R&D laboratories need this material for its role in creating enantiomerically pure therapeutics, where the specific (1R) configuration is essential for biological activity and regulatory approval.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of specific adrenergic receptor agonists and antagonists.
• API Synthesis: Used in the production route for cardiovascular and bronchodilator drugs where stereochemical purity is paramount.
• Asymmetric Synthesis: Employed as a starting material or resolving agent in chiral pool synthesis for complex molecule construction.
• Biochemical Research: Utilized in pharmacological studies to investigate structure-activity relationships (SAR) of phenethylamine derivatives.
• Process Development: Serves as a reference standard and intermediate in scaling up GMP-compliant manufacturing processes.
• Fine Chemical Production: Acts as a precursor for other specialty chemicals requiring the (1R)-1-(4-methoxyphenyl)ethanolamine scaffold.

Basic Information

Item	Details
Product Name	(1R)-1-(4-Methoxyphenyl)-2-(Methylamino)Ethanol
CAS No.	57286-93-8
Molecular Formula	C10H15NO2
Molecular Weight	181.23 g/mol
Synonyms	(R)-(-)-Methoxamine; (R)-1-(4-Methoxyphenyl)-2-methylaminoethanol; (1R)-1-(4-Methoxyphenyl)-2-(methylamino)ethan-1-ol; (R)-Methoxamine; (-)-Methoxamine; (R)-α-(1-Aminoethyl)-4-methoxybenzyl alcohol; 4-Methoxy-α-[(1R)-1-(methylamino)ethyl]benzenemethanol; L-Methoxamine
EINECS	Contact for details

Quality Control

Our (1R)-1-(4-Methoxyphenyl)-2-(Methylamino)Ethanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.