Description

5-(Chloromethyl)-1-Methyl-1H-1,2,3,4-Tetrazole is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the reactive chloromethyl group attached to the tetrazole ring, enabling efficient functionalization and serving as a key precursor for more complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing tetrazole bioisosteres used to mimic carboxylic acids for improved metabolic stability.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides, where the tetrazole moiety can enhance biological activity and selectivity.
• Ligand and Catalyst Development: Used to create specialized tetrazole-based ligands for coordination chemistry and catalysis, useful in asymmetric synthesis and material science.
• Polymer Chemistry: Serves as a functional monomer or cross-linking agent for producing polymers with specific thermal, mechanical, or responsive properties.
• Energetic Materials Research: Investigated as a building block for high-nitrogen content compounds and propellant formulations due to the tetrazole ring's energetic characteristics.
• Chemical Biology & Proteomics: Utilized in click chemistry and bioorthogonal reactions for labeling biomolecules or developing activity-based probes.

Basic Information

Product Name	5-(Chloromethyl)-1-Methyl-1H-1,2,3,4-Tetrazole
CAS No.	57235-84-4
Molecular Formula	C3H5ClN4
Molecular Weight	132.55 g/mol
Synonyms	1-Methyl-5-(chloromethyl)-1H-tetrazole; 5-Chloromethyl-1-methyltetrazole; 1-Methyl-1H-tetrazole-5-methanol, chloride; 1-Methyl-5-chloromethyltetrazole; 5-(Chloromethyl)-1-methyltetrazole; 1-Methyl-5-(chloromethyl)tetrazole; Tetrazole derivative C3H5ClN4
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request. Our quality management system supports cGMP and ISO standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation from atmospheric humidity. Store separately from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.