Description

2-Chloro-1-(2,3,4,5,6-Pentamethylphenyl)Ethan-1-One is a specialized chlorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in its unique sterically hindered pentamethylphenyl group, which provides exceptional selectivity and stability in complex chemical transformations. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring sterically hindered aromatic systems for enhanced metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where its structural motif can contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials that benefit from its rigid, multi-methylated aromatic core.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry, including Friedel-Crafts acylation and subsequent functionalization reactions.
• Fine Chemical Production: Used in the custom synthesis of complex, high-value specialty chemicals for various technological applications.

Basic Information

Product Name	2-Chloro-1-(2,3,4,5,6-Pentamethylphenyl)Ethan-1-One
CAS No.	57196-63-1
Molecular Formula	C13H17ClO
Molecular Weight	224.73 g/mol
Synonyms	2-Chloro-1-(pentamethylphenyl)ethanone; 2-Chloro-1-(2,3,4,5,6-pentamethylphenyl)ethan-1-one; Pentamethylphenacyl Chloride; 2-Chloro-1-(pentamethylphenyl)ethan-1-one; α-Chloropentamethylacetophenone; 1-(2,3,4,5,6-Pentamethylphenyl)-2-chloroethanone; 2-Chloro-1-(2,3,4,5,6-pentamethylphenyl)ethanone; CAS 57196-63-1
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-(2,3,4,5,6-Pentamethylphenyl)Ethan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specification parameters are provided and available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.