Description

tert-Butyl 2-(Aminooxy)Acetate is a versatile bifunctional organic building block featuring both a protected aminooxy group and a tert-butyl ester. This compound matters as a key reagent for the chemoselective modification of carbonyl compounds, enabling the synthesis of oxime ethers and other conjugates under mild conditions. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients, bioconjugation strategies, and advanced material science.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of oxime-based prodrugs, linker molecules for antibody-drug conjugates (ADCs), and other bioactive molecules.
• Bioconjugation Reagent: Used for site-specific labeling of proteins, antibodies, and peptides via reaction with ketone or aldehyde tags.
• Agrochemical Synthesis: Serves as a building block in the production of herbicides, fungicides, and plant growth regulators that incorporate aminooxy functionalities.
• Polymer Chemistry: Employed in the synthesis of functionalized polymers and dendrimers with reactive side chains for further modification.
• Material Science: Facilitates surface functionalization of nanoparticles and other materials to introduce specific chemical handles.
• Crosslinking Agent: Acts as a crosslinker for molecules containing carbonyl groups in hydrogel formation or material curing applications.
• Organic Synthesis: A valuable protected aminooxyacetic acid derivative for multi-step synthetic routes where orthogonal protection is required.

Basic Information

Product Name	tert-Butyl 2-(Aminooxy)Acetate
CAS No.	56834-02-7
Molecular Formula	C6H13NO3
Molecular Weight	147.17 g/mol
Synonyms	2-(Aminooxy)acetic acid tert-butyl ester; O-(tert-Butoxycarbonylmethyl)hydroxylamine; tert-Butyl O-(carboxymethyl)hydroxylamine; tert-Butyl aminooxyacetate; Boc-Aminooxyacetic acid; (tert-Butoxy)-N-hydroxyacetamide; Aminooxyacetic acid tert-butyl ester; N-(tert-Butoxycarbonylmethyl)hydroxylamine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Aminooxy)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with high-purity standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation. Keep away from strong acids and organic solvents. For long-term storage, desiccate to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.