Description

Tiacumicin B CAS NO 56645-60-4 is a potent macrocyclic antibiotic belonging to the tiacumicin class, primarily recognized for its significant activity against *Clostridium difficile*. This compound is of critical importance in the development of next-generation therapeutics targeting severe gastrointestinal infections. It is essential for pharmaceutical R&D, analytical reference standards, and the synthesis of advanced antibiotic formulations.

Application

• Pharmaceutical Active Ingredient (API): Core component in the development of novel antibiotics for treating *C. difficile*-associated diarrhea (CDAD) and other anaerobic bacterial infections.
• Research & Development: Serves as a critical reference standard and building block in microbiological, pharmacological, and synthetic chemistry research.
• Analytical Standard: Used for method development, validation, and quality control (QC/QA) in pharmaceutical laboratories to ensure product purity and potency.
• Precursor for Derivatives: Utilized in the semi-synthesis of more potent or targeted antimicrobial agents within the same chemical class.

Basic Information

Product Name	Tiacumicin B
CAS No.	56645-60-4
Molecular Formula	C₆₁H₈₈Cl₂O₂₈
Molecular Weight	1260.22 g/mol
Synonyms	Lipiarmycin B; Clostomicin B1; Tiacumicin B; FA-2-2B; OPT-80; PAR-101; Difimicin; (18E,20E,22E,24E,26E,28E,30E,32E,34E,36E,38E,40E,42E,44E,46E,48E,50E,52E,54E,56E,58E,60E)-62-Chloro-3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35,37,39,41,43,45,47,49,51,53,55,57,59,61-triacontahydroxy-4,6,8,10,12,14,16,18,20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,50,52,54,56,58,60,62-triacontaoxo-2H,63H-2,8:63,69-dimetheno-1H,64H-7,9a:15,10a-dimetheno[1,10]dioxacyclooctadecino[2,3-f:11,12-f']bis[1,4]benzodioxin-18-carboxylic Acid
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Quality Control

Our Tiacumicin B is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with high-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 2.0% Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.